Preheat your oven to 350°F (175°C) and prepare a 9x5-inch loaf pan.

In a bowl, beat together cream cheese and sugar until smooth, then add egg.

Whisk together flour, baking powder, baking soda, and salt.

Mix melted butter, sugar, and eggs, then stir in vanilla.

Combine wet and dry ingredients by folding gently until just mixed.

Gently fold in blueberries, ensuring they are evenly distributed.

Layer half of the batter in the pan, spread cream cheese filling, and cover with remaining batter.

Bake for 60-70 minutes until golden brown and toothpick comes out clean.

Let the bread cool in the pan for 10 minutes, then transfer to a wire rack.